STOCKHOLM: Scientists Katalin Kariko and Drew Weissman from Hungary and the United States respectively won the 2023 Nobel Prize in Physiology or Medicine for discoveries enabling the development of mRNA COVID-19 vaccines, the award-giving body said on Monday (Oct 2).
The prize, among the most prestigious in the scientific world, is selected by the Nobel Assembly of Sweden’s Karolinska Institute medical university and also comes with 11 million Swedish crowns (about US$1 million).
“The 2023 Nobel Prize in Physiology or Medicine has been awarded to Katalin Kariko and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19,” the body said.
Kariko was senior vice-president and head of RNA protein replacement at BioNTech until 2022 and has since acted as an adviser to the company. She is also a professor at the University of Szeged in Hungary and an adjunct professor at the University of Pennsylvania’s Perelman School of Medicine.
Weissman is a professor in vaccine research at the Perelman School.
Kariko found a way to prevent the immune system from launching an inflammatory reaction against lab-made mRNA, previously seen as a major hurdle against any therapeutic use of mRNA.
Together with Weissman, she showed in 2005 that adjustments to nucleosides, the molecular letters that write the mRNA’s genetic code, can keep the mRNA under the immune system’s radar.
“So this year’s Nobel Prize recognises their basic science discovery that fundamentally changed our understanding of how mRNA interacts with the immune system and had a major impact on society during the recent pandemic,” said Rickard Sandberg, member of the Nobel Assembly at Karolinska Institute
Source: CNA
